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Jule Inc jule gradient former
Jule Gradient Former, supplied by Jule Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/jule+gradient+former/jule+gradient+former/pm36852649-102-41-44
Average 90 stars, based on 1 article reviews
jule gradient former - by Bioz Stars, 2026-09
90/100 stars

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Gradient Centrifugation:

Article Title: The Upstream Conserved Regions (UCRs) Mediate Homo- and Hetero-oligomerization of Type 4 Cyclic Nucleotide Phosphodiesterases (PDE4s)
Article Snippet: .. Density gradient centrifugation Density gradients from 5 to 33 % sucrose in 50 mM Tris-HCl (pH 8.0), 150 mM NaCl, 1 mM EDTA, 0.2 mM EGTA, 10 mM NaF and 1.34 mM β-mercaptoethanol were prepared in 14x89-mm centrifugation tubes (Beckman Coulter Inc., Brea, CA) using the Jule gradient former (Jule Inc., New Haven, CT) as previously described [ 11 , 16 ]. .. The gradients were stored overnight at 4°C before they were loaded with 100 μl of the soluble cell extracts (100,000 × g supernatant) or marker proteins and centrifuged for 24 h at 36,000 rpm in a Beckman SW41 rotor (Beckman Coulter Inc., Brea, CA).

Centrifugation:

Article Title: The Upstream Conserved Regions (UCRs) Mediate Homo- and Hetero-oligomerization of Type 4 Cyclic Nucleotide Phosphodiesterases (PDE4s)
Article Snippet: .. Density gradient centrifugation Density gradients from 5 to 33 % sucrose in 50 mM Tris-HCl (pH 8.0), 150 mM NaCl, 1 mM EDTA, 0.2 mM EGTA, 10 mM NaF and 1.34 mM β-mercaptoethanol were prepared in 14x89-mm centrifugation tubes (Beckman Coulter Inc., Brea, CA) using the Jule gradient former (Jule Inc., New Haven, CT) as previously described [ 11 , 16 ]. .. The gradients were stored overnight at 4°C before they were loaded with 100 μl of the soluble cell extracts (100,000 × g supernatant) or marker proteins and centrifuged for 24 h at 36,000 rpm in a Beckman SW41 rotor (Beckman Coulter Inc., Brea, CA).

Generated:

Article Title: Intraflagellar Transport (IFT) Protein IFT25 Is a Phosphoprotein Component of IFT Complex B and Physically Interacts with IFT27 in Chlamydomonas
Article Snippet: Flagella in the supernatant fraction were harvested by centrifugation at 14,000 rpm (Eppendorf, 5415R) for 10 minutes at 4°C. .. Linear 12 ml 10–25% sucrose density gradients in 1×HMDEK buffer plus protease inhibitors were generated by using the Jule Gradient Former (Jule, Inc. Milford) and used within 1 hour. .. No more than 700 μl of cell body or flagella extracts were loaded on the top of the gradients and separated at 38,000 rpm, 4°C, for 14 hours in a SW41Ti rotor (Beckman Coulter).

Article Title: Chlamydomonas RABL4/IFT27 Mediates Phototaxis via Promoting BBSome-dependent Ciliary Export of Phospholipase D
Article Snippet: .. Linear 12 ml of 10-25% sucrose density gradients in 1×HMDEKN buffer plus protease inhibitors (1 mM PMSF, 50 μg/ml soybean trypsin inhibitor, 1 μg/ml pepstatin A, 2 μg/ml aprotinin, 1 μg/ml leupeptin) and 1% NP-40 were generated by using the Jule Gradient Former (Jule, Inc. Milford) and used within 1 hour. .. Cilia were opened by liquid nitrogen for three rounds of frozen-and-thaw cycles and centrifuged at 12,000 ×g , 4 °C, for 10 min. 700 micro-litter of ciliary extracts were then loaded on the top of the gradients and separated at 38,000 ×g , 4°C, for 14 hours in a SW41Ti rotor (Beckman Coulter).

Article Title: RABL4/IFT27 in a nucleotide-independent manner promotes phospholipase D ciliary retrieval via facilitating BBSome reassembly at the ciliary tip.
Article Snippet: Funding information National Natural Science Foundation of China; China Postdoctoral Science Foundation Abstract Certain ciliary transmembrane and membrane‐associated signaling proteins export from cilia as intraflagellar transport (IFT) cargoes in a BBSome‐dependent manner.. Upon reaching the ciliary tip via anterograde IFT, the BBSome disassembles before being reassembled to form an intact entity for cargo phospholipase D (PLD) coupling.. During this BBSome remodeling process, Chlamydomonas Rab‐like 4 GTPase IFT27, by binding its partner IFT25 to form the heterodimeric IFT25/27, is indispensable for BBSome reassembly.

Article Title: Bardet–Biedl syndrome 3 protein promotes ciliary exit of the signaling protein phospholipase D via the BBSome
Article Snippet: .. In brief, linear 12 mL of 10–25% sucrose density gradients in 1× HMDEK buffer plus protease inhibitors and 1% NP-40 were generated using the Jule Gradient Former (Jule Inc, Milford, CT) and used within 1 hr. ..



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